Alternate Raphael costume
Enter "LMSDD" as a password. Hold [L] or [R] when selecting Raphael at the character selection screen.
Alternate Michaelangelo costume
Enter "DLDSM" as a password. Hold [L] or [R] when selecting Michaelangelo at the character selection screen.
Alternate Donatello costume
Enter "SRSMM" as a password. Hold [L] or [R] when selecting Donatello at the character selection screen.
Alternate Leonardo costume
Enter "RMMLL" as a password. Hold [L] or [R] when selecting Leonardo at the character selection screen.
Halloween costumes
Enter "LRLMS" as a password. The turtles will have pumpkins on their heads.
Donatello has larger bandanna and double attack power
Enter "DRLDS" as a password.
Leonardo has larger bandanna and double attack power
Enter "LMLSD" as a password.
Michaelangelo has larger bandanna and double attack power
Enter "SMRDL" as a password.
Raphael has larger bandanna and double attack power
Enter "RDSRL" as a password.
Donatello has smaller bandanna and double defense power
Enter "LLSMR" as a password.
Leonardo has smaller bandanna and double defense power
Enter "SLDDS" as a password.
Michaelangelo has smaller bandanna and double defense power
Enter "MRLLD" as a password.
Raphael has smaller bandanna and double defense power
Enter "LSMDR" as a password.
Donatello flashes red and has double power-up effect
"Enter "SMLLR" as a password.
Leonardo flashes red and has double power-up effect
"Enter "MLLSR" as a password.
Raphael flashes red and has double power-up effect
"Enter "SRRLR" as a password.
Leonardo has unlimited normal shuriken
Enter "MSSRD" as a password.
Michaelangelo has improved defense
Enter "MSRMM" as a password.
Michaelangelo has unlimited exploding shuriken
Enter "MRRSL" as a password.
Master Splinter
Enter "LLMSR" as a password to unlock Master Splinter in story mode.
Playmates toy database
Enter "LSDRM" as a password.
Alternate hit sound effects
Enter "LSLSS" as a password.
Challenge mode
Successfully complete story mode as Raphael, Donatello, Michaelangelo, and Leonardo.
Casey Jones
Successfully complete level 1 as Raphael to unlock Casey Jones in versus mode. He does not have any Dojo missions in his story and does not get nearly as many intermission sequences as the turtles, but he is much stronger. Also, you cannot have another player play as your "assist" character when you are Casey Jones. He is the best all-around single player character, as he takes out most enemies with a single hit.
Evil Turtlebot
Successfully complete level 3 as Raphael, Donatello, Michaelangelo, or Leonardo to unlock the Evil Turtlebot in versus mode.
Hun
Successfully complete level 6 as Michaelangelo to unlock Hun in versus mode.
Oroku Saki
Defeat Saki as Raphael, Donatello, Michaelangelo, or Leonardo to unlock Oroku Saki in versus mode.
Shredder
Defeat Shredder as Raphael, Donatello, Michaelangelo, or Leonardo to unlock Shredder in versus mode.
Splinter
Successfully complete Dojo level 3 as Leonardo to unlock Splinter in versus mode.
Hamato Yoshi
Successfully complete Challenge Mode as Raphael, Donatello, Michaelangelo, or Leonardo to unlock Hamato Yoshi in versus mode.
Alternate costumes
Set the Xbox system date to December 25 to see the turtles with a Christmas theme. Set the Xbox system date to October 31 to see the turtles with a Halloween theme.
Easy challenge mode
The easiest way to complete challenge mode is to choose Donatello, since he has long reach. When you are facing such characters as Dr. Stockman, his jumping attack ability will take off a chunk of damage. After that, you face Shredder. Save a lot of shruriken. Throw fire/electric/ice shruriken at him until he dies. You will now face Oraki Saki. Do the same thing (if you have any shuriken remaining), or try to hit him with distant attacks. Also try to get combos on him. After you defeat him, you will face Hamato Yoshi. He has the same attacks as Oraki Saki, so basically do the same thing. After you defeat him, you will complete challenge mode and unlock Hamato Yoshi in versus mode.
Infinite combo
Note: Donatello is recommended for this trick because of his Long Bo. Fight any henchman (Purple Dragon member, Mouser, or Foot Clan) until he is about to collapse. Make sure your next to him before he disappears. Keep hitting him, but without landing a combo so that he will not fly away from you. By doing, so you will be able to rack up in combos as long as desired. The is done easier when at a corner or against a wall.
Enable the "Michaelangelo has unlimited exploding shuriken" code, then bounce any enemy into the corner. You do not have to be directly next to them to do this. Keep throwing Fire Stars until you are satisfied. The highest a combo can reach is 999.
Defeating Quarry
Quarry is difficult to defeat when you first fight him. He will continue teleporting after he does a certain amount of attacks or if you hurt him. The recommended turtle for fighting him is Donatello, because he has a huge reach as Quarry teleports. There is a chance you will continue striking him without turning your back. Micheleanglo is also just as good.
Defeating Razor Fist
The best way to do this is by either throwing special shrurikens at him, or letting him charge at you then jumping out of the way and hitting him in the back. It is difficult to get a hit on on his face, as he is blocking it with his fists and will charge or punch you if you attempt to do so.
Defeating Shredder
When Shredder is about to attack, throw a normal shuriken at him. This will stop him from attacking. Then, attack him with your combos. Repeat this and you will defeat Shredder without losing a lot of health. Note: Have over 15 normal shuriken with you.
Use the following trick to defeat Shredder when you have no shuriken or gembus remaining. Avoid all his attacks and stay away from him. However, remain close enough so that you are just out of his attack range. Wait patiently until Shredder attempts to do his main combination move, where he tries to stab you with the two prongs attached to his right hand, then attempts to slice you with the sword in his left hand three times then charges at you. When Shredder finishes his third attempt to slice you, and is just about to charge at you, he hesitates for a moment. This is long enough for you to charge and hit him with an extremely powerful combo.
Use the following trick to defeat Shredder flawlessly. Stay just out of his attack range and throw an electric shuriken at him. Shredder should now be crouching down and clutching his chest in pain. While he is in that position, dash around behind him. Just as he finishes getting up, hit him with a combo that will have him crouching again. Repeat this until Shredder is destroyed.
Energy Source in final episode
In the final episode, before defeating Shredder and Oroku Saki you will get into the Mouser Arsenal. After defeating the two Giant Mouser Robots and passing a lot of Foot Ninjas, you will reach an Energy Source. To destroy this annoyingly strong device, use Michelangelo. Do the jump attack (Eat Feet), then keep the [Left Analog-stick Up] and tap [Strong Attack] or [Weak Attack] to continue Eat Feet. Michelangelo will now do an infinite Eat Feet, which destroys the machine much faster.